-- John Keim, Bold prediction: New England running back James White will score two touchdowns, with his playing time rising because he's a top pass protector and the Redskins are a heavy blitz team. The Jaguars were leading the NFL in rush defense until giving up 210 yards and four rushing touchdowns in a loss at Philadelphia last weekend. Indianapolis' offensive efficiency might be a good match for Kansas City's offensive power. Stat to know: The Titans rank 28th in the NFL in both sacks allowed (17) and pressure rate (34.0%). The model also enters Week 5 of the 2021 season on an incredible 124-82 run on top-rated NFL picks that dates . 198 days ago NFL Week 4 of the 2022-23 NFL season has come to a close. Commanders WR Curtis Samuel has 26 receptions this season, tied with Travis Kelce and Davante Adams for eighth most in the NFL. ET | Fox But in Cooks' five career games against the Jaguars, he has averaged 120 yards with five touchdowns. They will welcome back Taylor Lewan from a four-game suspension with open arms. He has had 11 passes batted down at the line of scrimmage, six more than any quarterback in the NFL this season. -- Josh Weinfuss, Bold prediction: Arizona will double its sack total on the season and take Jalen Hurts down four times. Watch on ESPN+ More , Bold prediction: Nope. Read more. No 49ers player has done that in three straight games since Billy Kilmer in 1961. -- Jordan Raanan, Bold prediction: Minnesota will bench Diggs in Week 5 to send a message to the star receiver, especially after he missed practice for non-football injury-related reasons earlier in the week. So this is a game the Chargers normally would lose, which is why Im picking them to win -- along with the fact that I believe the Giants will have trouble stopping the Bolts talented pass-rushing duo of Melvin Ingram and Joey Bosa. Raiders 23, Ravens 16 -- Paul Gutierrez, Three key players from the Packers playoff victory over the Cowboys are gone -- Jared Cook (the tight end who caught the sideline pass to set up the game-winning field goal), Micah Hyde (the safety who had an interception) and T.J. Lang (the Pro Bowl guard who protected Aaron Rodgers). Arizona has given up 17 sacks while the Eagles have 10 on the season, but Palmer called the Eagles' front seven one of the best he will face this year. Weinfuss' pick: Cardinals 20, Bengals 17 The versatile back is now on pace for 115 catches this season. Bengals 14, Bills 10 -- Katherine Terrell, Coach Todd Bowles says "2-2 is nothing to brag about." ET | ESPN/ESPN App See Week 5 rankings. Here are some lines that could change after this week's slate concludes. The 2023 NFL draft wrapped up Saturday and through five rounds, 12 quarterbacks were selected -- the most in the common draft era. The Packers opened the season with a disastrous loss at New Orleans . -- Marcel Louis-Jacques. Spread: KC -7.0 (51), What to watch for: The Raiders might need to score a big number in order to win. Meanwhile, Mahomes has thrown two interceptions, and the team has also lost two fumbles through four games. NFL Power Rankings Week 5 bet now, bet later Week 5 spot bets Under 50.5 (-110) Combined, both teams have begun the season 3-5 O/U while the Bengals are riding a three-game Under. Read more. HOU-JAX | SF-CAR | PHI-ARI Full list of Mr. Irrelevants in NFL draft history: Is Brock Purdy already the best final pick? FPI prediction: KC, 80.9% (by an average of 12.0 points), Matchup must-reads: Mahomes, Favre and other NFL stars reveal the larger-than-life tales behind Andy Reid Colts GM Chris Ballard has needed his no-flinch, no-panic approach Chiefs RB Williams has waited behind big-name backs before Ebron 'disgusted' by drops, takes blame for Colts' loss, Monday, 8:15 p.m. ET | CBS Since the start of last season, 13 of the Bills' 20 games have gone under. Reiss' pick: Patriots 30, Redskins 6 DET-NE | CHI-MIN | MIA-NYJ It all culminates with a Monday Night Football matchup between the Raiders and the Chiefs on ESPN. -- Brady Henderson. The Week 5 NFL schedule for the 2022 season is stacked with great matchups, and we have you covered with what you need to know heading into the weekend. -- Paul Gutierrez. The 61-0 streak is over: Why the Ravens are no longer the NFL's best closers, Monday 8:15 p.m. Read more. The answer is to be determined, Cruz expects Minshew will lead Jags over Allen's Panthers (1:17), Week 5 NFL game picks, schedule guide, fantasy football tips and more, Which NFL teams still have roster holes? What to know for fantasy: Pittsburgh's Diontae Johnson owns a 20.5% target share this season from Rudolph, up from his 9.7% rate with Ben Roethlisberger under center. NFL Week 5 Expert Picks - Straight Up - CBS Sports But to this point, Steelers quarterback Mason Rudolph hasn't been able to take advantage of the vertical game, averaging just 3.3 air yards per completion, the lowest for any quarterback with 50 completions since 2006. But Trubisky is making his first career start on Monday Night Football. Watch on ESPN+, Bold prediction: Ravens rookie receiver Marquise Brown gets back on track after two lackluster games with 100 yards receiving and two long touchdown catches. -- Adam Teicher, Bold prediction: Raiders cornerback Amik Robertson will have a takeaway against the Chiefs. That would mean bigger roles for undrafted rookie Keelan Cole (four catches) and recently signed first-year player Max McCaffrey. Irrelevant' pick on Toledo's Johnson, Chargers go all-in on TCU with Duggan pick in 7th, 10 fantasy football breakout players for 2023, Will Levis opens up about emotional draft day, Steelers' first draft under Omar Khan was 'aggressive' and achieved high marks, After hoopla of going No. Rams 24, Seahawks 23 -- Brady Henderson, The Rams are feeling really good about themselves, coming off a big road win against the Cowboys. These two teams just played each other in the regular season finale last week when the Roughnecks won 25-9 despite Brandon Silvers, Max Borghi, Deontay Burnett, and Brycen Alleyne all sitting. Legwold's pick: Chargers 23, Broncos 21 -- Katherine Terrell, Bold prediction: Ryan Neal will take over for Josh Jones in the starting lineup and spark Seattle's struggling defense with a game-changing takeaway. Matchup rating: 53.8 | Spread: TEN -3 (38.5), What to watch for: Marcus Mariota has not thrown an interception this season, but the Bills are tied with the Giants and 49ers for second in the NFL with five picks each. ET | CBS Even without D'Andre Swift, the Lions' ground attack is rolling, and that won't stop against New England. All newly updated picks . Stat to know: The Rams have been outscored 44-3 with an NFL-worst minus-41 point differential in the fourth quarter this season -- they have outscored opponents by 17 in the first three quarters. NFL picks, predictions for Week 5: Cardinals crush 49ers; Steelers stop 3 all-time rusher Barry Sanders, 1 p.m. Stat to know: Daniel Jones needs two passing touchdowns and 72 passing yards to have the most in each category by a Giants quarterback in his first three NFL starts since the 1970 merger. The Saints quarterback is remarkably 2-0 as Drew Brees' replacement, but he has thrown for an average of only 185 yards per game in those two starts. While he acquitted himself generally well in a tough spot when Mailata went down against the Jaguars on Sunday, Arizona should have some opportunities to affect the passer. -- Todd Archer. Without Tyreek Hill, Chiefs' receiving load shifting to tight ends and backs Patrick Mahomes says Andy Reid 'stole the show' in TV ad, 9:30 a.m. The Vikings sacked Lions quarterback Matthew Stafford six times in a losing effort last week. passing windows despite a smaller 5-foot-10, 204-pound frame. Watch the latest episode, Bold prediction: Cleveland running back Nick Chubb rushes for more than 100 yards against San Francisco's No. Yes, he's 2-0, but the Saints will need more from Bridgewater, 1 p.m. See Week 5 rankings. Betting nugget: This is the 63rd straight regular-season game that Brady will be favored in, breaking a tie with Steve Young (1993-97) for the longest streak by a quarterback in the Super Bowl era. Not super bold, but scoring even just a little over 30 points will be enough for the Chiefs to win. Matchup rating: 42.5 | Spread: MIN -5.5 (43.5), What to watch for: How will Kirk Cousins perform vs. the Giants' 25th-ranked pass defense, which is allowing 279.5 yards per game. Cimini's pick: Eagles 27, Jets 9 Betting nugget: Carolina is 3-15 ATS in its past 18 games. The team has preached all week that their offense won't change much with the backup quarterback starting, and he'll prove them right come Sunday. Stat to know: Jacoby Brissett is fifth in both QBR (75) and completion percentage (74%) in home games this season. That was a reminder that their defense remains one of the NFL's best. FPI prediction: HOU, 64.0% (by an average of 5.0 points), Matchup must-reads: How Watson's 'NFL experience' began as ball boy for the Falcons TE Hooper could be the next Falcon to cash in Quinn not worried about job, his staff, 1 p.m. This week's draft seemingly begins with the second overall pick -- excluding Tuesday's wild odds move for the top pick -- but it could take a few wild turns right after that. Expect the Texans to feed the Jaguars a heavy dose of Pierce, especially with run-game anchor Foley Fatukasi dealing with a quad injury. Most important, Rodgers is 13-2 in those games, dating back to 2008. 2022 NFL Expert Picks | ESPN The Cards are dead last in the league with four sacks entering Week 5. Betting nugget: The Broncos are 1-7 ATS in their past eight games. Read more. The Bills and Steelers matchup, discussed in greater detail below, moved from Buffalo minus-8 to Buffalo minus-14, but a perhaps. -- Josh Weinfuss. -- David Newton, Bold prediction: McCaffrey surpasses 100 yards rushing and receiving. See Week 5 rankings. Matchup rating: 9.9 | Spread: CIN -3 (46.5), What to watch for: The game between winless teams could feature multiple sacks. Teicher's pick: Chiefs 35, Colts 27 FPI prediction: TEN, 74.0% (by an average of 8.9 points), Matchup must-reads: Taylor Lewan's return could be a boon for Titans' offense Allen progressing but still in protocol Gore closing on No. NFL Expert Picks - Super Bowl Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 Week 9 Week 10 Week 11 Week 12 Week 13 Week 14 Week 15 Week 16 Week 17 Week 18 Wild Card Divisional Round Conference Championship Super Bowl hidden ET | CBS -- Sarah Barshop, Bold prediction: The Falcons, who have been outscored 38-10 in first quarters this season, will actually have the lead after the first frame in Houston. -- Michael Rothstein. NFL Week 5 picks, predictions: Colts vs. Broncos | Giants vs. Packers | Steelers vs. Bills Chargers vs. Browns | Texans vs. Jaguars | Bears vs. Vikings Lions vs. Patriots | Seahawks vs.. -- Todd Archer, Bold prediction: The first team to 30 rushing attempts will win. The NFL Week 5 schedule features a bevy of intriguing matchups including the Rams vs. Seahawks on Thursday Night Football in a matchup between two NFC East teams with championship aspirations; the Browns vs. Chargers in a battle between two surprising contenders in the AFC; the 49ers vs. Cardinals in a critical NFC West tilt featuring MVP Matchup rating: 40.4 | Spread: CAR -3.5 (41), What to watch for: Both teams will be relying on top running backs from the 2017 draft to take the pressure off young quarterbacks. ET | ESPN Since 2011, games with totals of 55 or higher are 33-22-1 to the over. The answer is to be determined. ET | Fox The story of the Cowboys scout and prospect son Dallas just drafted, Legacy pick: Cardinals take great-great-nephew of team's first-ever draft pick, Winston already improving under 'QB whisperer' Bruce Arians, Yes, he's 2-0, but the Saints will need more from Bridgewater, Matthew Berry's Love/Hate for Week 5: How to make a trade, NFL experts predict: Week 5 upset picks, fantasy football flops and sleepers, How Watson's 'NFL experience' began as ball boy for the Falcons, TE Hooper could be the next Falcon to cash in, Taylor Lewan's return could be a boon for Titans' offense, Gore closing on No. -- Courtney Cronin. That doesnt mean theyll have an easy time against Houston rookie QB Deshaun Watson. Wells' pick: Chiefs 41, Colts 24 See Week 5 rankings. Read more. . Jets' high-priced, underperforming offensive line receives wake-up call, Eagles RBs coach Duce Staley: 'A lot of Jordan and a lot of Miles', Fournette flourishes in Christian McCaffrey-type workload, Amid defensive changes, Kuechly remains the Panthers' stopper, Jaguars looking to cash in on Minshew mania, Cardinals WR Kirk likely out Sunday but ankle better, Bengals put WR Ross on IR with shoulder injury, Broncos' 'world of suck' won't be easily fixed, How Chargers kept team from splintering during Gordon holdout, Chubb's injury further exposes Broncos' house of cards, Elliott took poor game personally, aims to rebound vs. Packers, The Graham mistake 2.0: TE a rare miss for Packers GM, With Elliott next, Packers have to get run defense on track in a hurry, Leighton Vander Esch's star rising as fast off field as on it, For Randall Cobb, Packers game just another week, Mahomes, Favre and other NFL stars reveal the larger-than-life tales behind Andy Reid, Colts GM Chris Ballard has needed his no-flinch, no-panic approach, Chiefs RB Williams has waited behind big-name backs before, Ebron 'disgusted' by drops, takes blame for Colts' loss, Chubb's running finally launches Browns' offense, How good are first-place 49ers? He's a bad matchup for the Jaguars because they've had issues covering backs out of the backfield. FREE to play! The Saints, meanwhile, have committed an NFL-high 11 turnovers -- including five interceptions in three games from Jameis Winston -- so the opportunity will be there. Los Angeles Chargers at New Orleans Saints. This is a matchup of the worst passing offense in the NFL (Jets, 131 yards per game) vs. the worst passing defense (324 yards per game). It prompted Packers coach Matt LaFleur to say this week that defensive coordinator Joe Barry needs to have his players "play more physical" and "in certain situations you might have to put an extra defender in the box." These two teams played last year in similar circumstances, with the Titans leaving with the victory due to Mariota's four touchdowns and a stout running game. Read more. FPI prediction: LAC, 57.5% (by an average of 2.3 points), Matchup must-reads: Chargers hope to get on track Browns' schedule gets difficult from now on Garrett back at Browns practice for first time since car crash, What to watch for: It looks like another week without Winston and wide receiver Michael Thomas, which would mean Andy Dalton will likely take over again at quarterback. NFL Week 5 picks, schedule, odds, injuries, stats, fantasy tips With coaching staff in place, what's next for Carolina Panthers? Read more. The Colts, meanwhile, are scoring on 40% of their possessions, 11th best. TB-NO | ATL-HOU | BUF-TEN Stat to know: The Patriots are looking to become the first team since the 1988 Browns and Dolphins to allow zero passing touchdowns in the first five games of the season. That stat line would be worth 259.6 points, not much different from the 260.1 points that Allen produced last season. Just like in life, it . Through four games, Kupp has been targeted 54 times with 42 catches for 402 yards. He needs nine receptions on Sunday to break the five-game record, held by Zach Ertz (2018) and Eric Johnson (2004). Stat to know: Joe Burrow has 12 touchdowns on passes of 20-plus yards downfield since the start of last season. Betting nugget: All four Bills games have gone under the total this season. Chicago head coach Matt Nagy is high on veteran backup quarterback Chase Daniel, who's starting in place of Mitchell Trubisky (left shoulder), but Nagy still wants to control the clock and pound the ball with Montgomery. Let's get into the full Week 5 slate, including another London showdown (Giants-Packers), Kenny Pickett's first start, Jalen Hurts vs. Kyler Murray and an AFC North meeting between the Bengals and Ravens. Read more. -- Turron Davenport. Betting nugget: Last season, first-round quarterbacks making their first career starts went 0-5 ATS. -- Rob Demovsky. It sounds crazy, but the Jets will win their third straight game. Stat to know: Chiefs running back LeSean McCoy has three scrimmage touchdowns this season, matching his total in 14 games last season. Betting nugget: Both times Rodgers faced the Cowboys in Dallas, Green Bay won the game outright as an underdog (2016 divisional round and 2017 Week 5). And for fantasy managers looking to make all the right moves, Graziano and Fowler name must-start sleepers and point out potential fantasy flops of the week. Time/station: 8:20 PM EST, ESPN. -- DJ Bien-Aime. Experts predict Week 5 NFL upset picks, fantasy football - ESPN The last thing the Vikings need is for Diggs' situation to blow up into a full-blown distraction. ESPN researcher Kyle Soppe hands out helpful fantasy football intel, as well. DiRocco's pick: Panthers 17, Jaguars 16 Stat to know: The Eagles are the only team to win the turnover battle in every game this season. With the return of Michael Gallup, Lamb will have chances to get away from Jalen Ramsey to make more plays. Inside Jets' trade pursuit of Tyreek Hill, and how they rebounded Dolphins say QB Tua Tagovailoa ruled out for Week 5 game vs. New York Jets, What to watch for: Justin Herbert finished with 398 passing yards in the Chargers' win over the Browns last season, the most Cleveland surrendered in any game in 2021. See Week 5 rankings. Victor Cruz contends that Gardner Minshew is better equipped to lead his team to victory in the matchup with Panthers QB Kyle Allen. Read more. This feels like it could go either way, but the edge goes to the home team. ESPN. Projecting the Giant's first-round pick, Moody's pick: Saints 27, Seahawks 24 With DT Fletcher Cox still working through a calf injury, there's a chance Palmer will have a little more time to operate. Steelers 24, Jaguars 10 -- Mike DiRocco, The Steelers' offense is poised to break out eventually; Ben Roethlisberger has only one completion of more than 40 yards this season -- which came in Week 2, his only home game. They haven't lost three straight road games since 2018. He is leading the NFL in sacks and pressures this year. Jalen Ramsey to the Eagles: What are the realistic odds? Jets' high-priced, underperforming offensive line receives wake-up call Eagles RBs coach Duce Staley: 'A lot of Jordan and a lot of Miles', 1 p.m. Last year alone, Mahomes threw seven touchdowns with no interceptions in two games as the Chiefs scored a combined 89 points. NFL odds Week 5: Betting results for every game | FOX Sports He started slow, but has run for 199 yards combined the past two weeks and ranks third in the NFL in yards after first contact at 3.21 in that time. NFL Nation reporters give their picks for Week 5, including whether the Cowboys can bounce back against Aaron Rodgers and the Packers. -- Brooke Pryor. -- Eric Woodyard. Stat to know: Rodgers is averaging 6.2 air yards per attempt, his fewest through four games since becoming a starter in 2008. Stat to know: Chargers receiver Keenan Allen leads the NFL with 452 receiving yards, and he is the only player with more than 400. Betting nugget: Over the past five seasons, Miami is 13-7 ATS as a favorite. See Week 5 rankings. NFL picks against the spread for Week 5. NFL odds, Vegas lines, picks, spreads, bets, predictions for Week 5 That will make it even harder for the Jaguars to do much in the passing game, especially downfield, to open things up for RB Leonard Fournette. They have an NFL-best plus-eight turnover margin. NFL odds, lines, picks, spreads, best bets, predictions for Week 5 Vikings 20, Bears 17 -- Courtney Cronin, The Bears are 14-2 in their past 16 home games against the Vikings dating back to the 2001 season. FPI prediction: MIN, 71.6% (by an average of 7.9 points), Matchup must-reads: Jones brings new energy, hope to Giants What's happened to Thielen and Diggs? Read more. Betting nugget: Minnesota is 22-10-1 ATS after a loss under Mike Zimmer. But theyll defeat him as they have other young quarterbacks except for Oaklands Derek Carr as a rookie in 2014. They also have a good secondary, which already has five interceptions. They'll be energized, while at home against a tough division rival, and will sneak out another close win. Williams' pick: Chargers 27, Broncos 20 NFL Draft 2023: Ranking all 31 first-round picks as Eagles, Steelers He will etch his name in the record books, joining Jim Brown in 1958 as the second player in league history to score multiple touchdowns in four of the team's first five games. Stat to know: The Vikings have allowed at least 300 yards in 12 straight games dating back to last season.
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